解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Rearrangements of the immunoglobulin heavy chain joining region (JH) genes occur in some T lymphocytes, probably because the mechanism for assembly of T-cell receptor encoded genes is very similar to that for immunoglobulins. Two such rearrangements described previously represented proper fusion of a DH and JH gene. W...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345502
更新日期:1988-01-01 00:00:00
abstract::The Ly-5 system of the mouse defines a set of transmembrane glycoprotein isoforms (T200, B220, etc) that hallmark various lineages and stages of hematopoietic differentiation. These isoforms are the products of a single Ly-5 gene comprising 34 exons, 32 of them (Exs-3-34) protein-coding and three (Exs-5-7) selectively...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345505
更新日期:1988-01-01 00:00:00
abstract::Probes for loci situated near one end of the proximal (Tcp-1) and distal (Qa-2, 3) inversions of the mouse t complex have been hybridized to chromosomes of mice with and without t complexes and with morphologically distinguishable chromosome 17s. Both the probe for Tcp-1 and that for Qa-2, 3 hybridized to clearly diff...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00395134
更新日期:1988-01-01 00:00:00
abstract::Mouse lymphocyte alloantigens Ly-19 and Ly-32 are controlled by the genes tightly linked to the Lyb-2 locus on chromosome 4. Despite the similarity in mouse strain distribution patterns, Ly-19 and Ly-32 antigens which have been detected on both B- and T-cell lineages are distinct from Lyb-2 antigen whose expression is...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364229
更新日期:1988-01-01 00:00:00
abstract::A retrovirus element (TLev1) is located within the Thymus leukemia antigen (Tla) locus of the C57BL/10 mouse major histocompatibility complex. Low-copy probes have been isolated from sequences flanking the TLev1 integration site to examine the distribution of TLev1 among inbred mouse strains having genotypically deter...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345501
更新日期:1988-01-01 00:00:00
abstract::Mechanisms to account for the unusual properties of a DR1 alpha beta complex (designated DRgp50) that is resistant to dissociation under normal conditions utilized were investigated. Expression of this DRgp50 complex is highly correlated with the failure of cells from certain DR1 individuals (DR1x) to stimulate specif...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00375856
更新日期:1988-01-01 00:00:00
abstract::The potential association between integration or deletion of mouse mammary tumor virus (MMTV) retroviral sequences and the appearance of non-H-2 histocompatibility (H) antigen mutations was investigated. Genomic blots from inbred strains carrying 22 loss, gain-loss, and gain mutations on the BALB/c and C57BL/6 backgro...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345461
更新日期:1987-01-01 00:00:00
abstract::Chickens of the Iowa State S1 line have been selected for ability to regress Rous sarcoma virus-induced (RSV) tumors, humoral immune response to GAT (Ir-GAT), and erythrocyte antigen B. Sublines homozygous at the major histocompatibility complex (MHC), as well as F1 heterozygotes and F2 segregants, were tested for res...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00404420
更新日期:1987-01-01 00:00:00
abstract::To analyze how many D-region-encoded molecules could be detected in H-2q, we produced a panel of nine monoclonal antibodies from AKR (KkDk) anti-AKR.M (KkDq) immunizations. All of the Dq region antibodies cross-reacted on Dd and/or Ld, and all except one cross-reacted on Db, confirming the previously observed serologi...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00768827
更新日期:1987-01-01 00:00:00
abstract::The major histocompatibility complex of the rat (RT1) encodes the class II molecules involved with antigen presentation and cell to cell communication. The organization of these class II genes has been studied by Southern blot hybridization using genomic DNA from inbred and recombinant rat strains digested with variou...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00346516
更新日期:1987-01-01 00:00:00
abstract::The polymorphism of feline MHC antigens was examined using biochemical methods. The following observations were made: (1) feline class I and II antigens are polymorphic. Their biochemical features were established using rabbit and mouse reagents directed against human MHC products; they resemble those observed for oth...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00398799
更新日期:1986-01-01 00:00:00
abstract::Segregation distortion was found for a haplotype of the equine lymphocyte antigen (ELA) system in an extended family of American Standardbred horses. In one sire family, consisting of a stallion and his 17 sons and grandsons, the gene for ELA-A10 (A10) was transmitted to 57.7% of 638 offspring scored (P = 0.001). Sign...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364526
更新日期:1986-01-01 00:00:00
abstract::The complexity and polymorphism of sequences related to the class I and class II genes of mammalian major histocompatibility complexes (MHCs) were investigated in the tassel-eared squirrel subspecies Sciurus aberti kaibabensis or Kaibab squirrel. Kaibab squirrels are geographically isolated on the Kaibab plateau north...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364527
更新日期:1986-01-01 00:00:00
abstract::The incidence of arthritis and the antibody response to mouse and to rat type II collagen after immunization with native rat type II collagen was studied in different mouse strains, including wild mouse-derived strains belonging to the H-2p/H-2q family. High serum levels of antibodies to mouse and rat type II collagen...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00373114
更新日期:1986-01-01 00:00:00
abstract::Genes of the major histocompatibility complex (MHC) in the mouse (H-2 complex) have been shown to be an important factor in determining the immune responsiveness of various strains of mice to isolated antigens (e.g., lysozyme). The role of MHC genes in controlling the responsiveness of mice to multiple alloantigens is...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00376519
更新日期:1986-01-01 00:00:00
abstract::Immunogenicity for T cell-independent B-cell response assessed by splenic plaque-forming cell (PFC) response and cell-surface expression measured by laser flow cytometry of various class I H-2 antigens on mouse red blood cells (RBC) were compared. It was found that the order of magnitude of both immunogenicity and cel...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00372295
更新日期:1986-01-01 00:00:00
abstract::One mouse with a known recombination (NAK) at the Igk locus on chromosome 6 and two new recombinants [B6.PL (75NS) and B6.PL (85NS)] were examined using a series of probes, each of which is specific for a set of immunoglobulin (Ig) Vk genes. Under high stringency conditions, each probe detects from 1 to 19 Bam HI rest...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00373021
更新日期:1986-01-01 00:00:00
abstract::Footpad swelling response was used to measure the alloantigenicity of epidermal cells (ECs) in delayed-type hypersensitivity (DTH). Strong footpad swelling was observed 3 h after the challenge, and it continued for 48 h after the challenge. Genetical incompatibility between the recipients and the ECs was required to i...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00372666
更新日期:1986-01-01 00:00:00
abstract::The mechanisms underlying Ir gene control of CMI were addressed by examining the DTH and Tprlf responses specific for the synthetic polymers GT, GAT, and GA. We show that BALB/c mice (GAT/GA responders, GT nonresponders) primed with GT fail to develop DTH and Tprlf responses specific for GT, GAT, or GA. GAT immunizati...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00398791
更新日期:1986-01-01 00:00:00
abstract::Human cDNA probes for 21-hydroxylase (21-OH) and for complement component C4 are used on restriction digests of the members of several families with interesting supratypes. The presence of two Taq I fragments of 3.7 kb and 3.2 kb in size with a 21-OH probe is confirmed in most individuals who show no evidence of C4 de...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00377968
更新日期:1986-01-01 00:00:00
abstract::TL antigens are class I glycoproteins which are expressed on thymocytes and which are coded by the Tla region of the major histocompatibility complex of the mouse. Biochemical analysis of TL molecules from different strains of mice revealed structural variation determined by the Tla region which is detectable by pepti...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00373117
更新日期:1986-01-01 00:00:00
abstract::The cell-surface expression of the class I alloantigen Qa-2 was analyzed on resting and activated spleen and thymus cells using cytotoxic elimination and immunofluorescence and flow cytometry. Spleen cells activated by mitogens or alloantigen were homogeneously positive for cell surface Qa-2, but activated splenic T c...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00377958
更新日期:1986-01-01 00:00:00
abstract::The Mep-1 gene on chromosome 17 in mice controls the activity of meprin, a kidney brush border metalloendopeptidase. Most inbred mouse strains of the k haplotype (e.g., CBA, C3H, AKR) are markedly deficient in meprin activity; these mice carry the Mep-1b allele. Mouse strains in which meprin activity levels are normal...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00430310
更新日期:1985-01-01 00:00:00
abstract::In this report we present data demonstrating the endogenous expression of I-region associated (Ia) antigens on a cloned line of mouse T cells, CTLL, as well as transcription of the invariant chain gene in these cells. We demonstrate further that this Ia-bearing T-cell clone, CTLL, can utilize the expressed Ia molecule...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00563509
更新日期:1985-01-01 00:00:00
abstract::Recombinant inbred strains were used to demonstrate the existence of a major locus on chromosome 1, designated Sap, which controls the endogenous concentration of the mouse acute phase reactant, serum amyloid P-component (SAP). Levels of SAP were associated with alleles at the Ly-9 locus in two sets of RI strains: BXD...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00430920
更新日期:1985-01-01 00:00:00
abstract::Eight families (121 individuals) with two or more members affected with systemic lupus erythematosus (SLE) were analyzed for histocompatibility antigens (HLA-A, B, C, DR, MT, and MB) and complement antigens (C4A, C4B, and BF). These data were correlated with serological markers (antinuclear antibodies, single- and dou...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00430796
更新日期:1985-01-01 00:00:00
abstract::In the mouse three lymphocyte gene families have been positioned on the proximal region of chromosome 6. Originally the immunoglobulin kappa light chain (Igk) and the thymocyte surface antigens Lyt-2 and Lyt-3 were assigned to chromosome 6, and recently the beta chain of the T-cell receptor for antigen was positioned ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00404487
更新日期:1985-01-01 00:00:00
abstract::In a series of newly isolated AKR leukemias, some tumors expressed large amounts of both H-2K and H-2D molecules, while others had reduced levels of both antigens. The number of H-2 antigens expressed in steady state showed a consistent correlation with the rate of synthesis of the H-2 class I heavy chain and the beta...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00418093
更新日期:1985-01-01 00:00:00
abstract::The chromosomal assignment of the gene encoding the invariant (Ii) chain associated with the mouse immune response antigens (Ia) was determined by Southern blot analysis of DNA from a panel of mouse X Chinese hamster somatic cell hybrids cleaved with Hind III or Eco RI. Using a mouse li cDNA as a hybridization probe, ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00372244
更新日期:1985-01-01 00:00:00
abstract::The serological reactivities of HLA-A3, -B7, and -CW3 heavy chains associated with either mouse, bovine, or human beta-2-microglobulin (beta 2m) and expressed on the surface of transfected mouse fibroblasts were analyzed. All reactivities associated with one cluster (defined by monoclonal antibody W6/32) of antigenic ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00430798
更新日期:1985-01-01 00:00:00
abstract::The immune response of the rat to group A streptococcal carbohydrate (SACHO) and an associated idiotype, Id-1, was used to examine the effect of paternal immunity on Id-1 and SACHO-specific antibody expression by the offspring. First litters, conceived before immunization of the father, had significantly higher Id-1 l...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00372236
更新日期:1985-01-01 00:00:00
abstract::Four cDNA probes for the human major histocompatibility complex (MHC) were used to investigate the sheep MHC, in conjunction with serological typing for ovine lymphocyte antigen (OLA). Lymphocytes from a family (two parents and five offspring) of Romanov sheep were subjected to genomic DNA digestion by the restriction...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00430918
更新日期:1985-01-01 00:00:00
abstract::A mouse monoclonal antibody, Mo. Ab. 108.45, detecting cell-surface determinants associated with the T-cell receptor for alloantigen was produced by immunizing mice with an alloreactive human T-cell clone and fusing the splenocytes with the NS1 plasmocytoma. This Mo. Ab. reacts with the immunizing T-cell clone but not...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345614
更新日期:1984-01-01 00:00:00
abstract::Early and late primary IgM antibody responses of mice to Thy-1.1 antigens showed different antigenic and cellular requirements. We studied genetic controls of the early primary responses, which could be induced by subcellular thymocyte antigens independently of host T-cell activity. All Thy-1.2 mouse strains of Igha (...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364214
更新日期:1984-01-01 00:00:00
abstract::Mutants of the EB virus-transformed cell line T5-1 (HLA-A1, 2; B8, 27), bearing well-characterized alterations in HLA-A2 antigen expression and unable to bind the HLA-A2-specific monoclonal antibody BB7.2, have been tested for their susceptibility to EB virus-specific cytolysis using effector T-cell preparations funct...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00403438
更新日期:1984-01-01 00:00:00
abstract::Genetically anemic W/Wv mice and lethally irradiated wild-type mice were cured and populated by grafted marrow cells from donor mice of three congenic lines that differed at non-H-2 histocompatibility loci. Tail skin from mice of the same congenic lines was grafted 3-4 weeks later. In two cases, the recipients behaved...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00403441
更新日期:1984-01-01 00:00:00
abstract::The genetic control of natural resistance in vivo to four natural killer (NK) cell-resistant H-2 homozygous lymphoid tumor cell lines was investigated by following the survival and organ distribution of cells prelabeled with radioactive iododeoxyuridine. Backcross mice derived from DBA/2J and CBA/J parents were inject...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364210
更新日期:1984-01-01 00:00:00
abstract::Class I-like molecules have been immunoprecipitated from Xenopus leukocytes and erythrocytes with alloantisera directed against major histocompatibility complex (MHC)-linked antigens. The heavy chains, depending on the allele examined, have molecular weights of 40 000-44 000 of which 3000 daltons are asparagine-linked...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345617
更新日期:1984-01-01 00:00:00
abstract::We have reported that susceptibility to glucocorticoid- and phenytoin-induced cleft palate and glucocorticoid receptor levels in mice are influenced by the H-2 histocompatibility complex on chromosome 17. Phenytoin competes with glucocorticoids for the glucocorticoid receptor and inhibits production of prostaglandins ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00430325
更新日期:1984-01-01 00:00:00
abstract::Monoclonal antibodies reacting with TL-like class I antigens expressed on the surface of human thymocytes and some T leukemia lines were found to define three independent epitopic clusters, two of which could be shown to reside on serologically distinct molecular subsets by a solid-phase radioimmunoassay as well as by...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364207
更新日期:1984-01-01 00:00:00